2 de diciembre de 2012, 23:22
| 02/12 | 11:30 | Real Betis Balompié B | 2 - 3 | CD San Roque de Lepe |
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| 02/12 | 11:30 | Cádiz CF | 0 - 1 | UD Melilla |
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| 02/12 | 12:00 | CP Cacereño | 1 - 1 | Loja CD |
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| 02/12 | 16:00 | UCAM Murcia CF | 0 - 1 | RB Linense |
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| 02/12 | 17:00 | Écija Balompié | 0 - 2 | Lucena CF |
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| 02/12 | 17:00 | Albacete Balompié | 3 - 1 | Atlético Sanluqueño CF |
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| 02/12 | 17:00 | CF Villanovense | 0 - 0 | Sevilla FC Atlético |
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| 02/12 | 17:00 | San Fernando CD | 2 - 0 | FC Cartagena |
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| 02/12 | 17:00 | UD Almería B | 0 - 0 | Arroyo CP |
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| 02/12 | 17:00 | Real Jaén CF | 0 - 0 | La Roda CF |
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Total goles: 17 - Promedio: 1,70
